The Stress Inflammation Cycle: Understanding the Connection

Did you know that chronic stress can lead to persistent inflammation in the body? As a 75-year-old vitalist clinical herbalist and long-term wellness advocate, I’ve experienced firsthand the profound impact of stress on our health. Let’s explore the fascinating world of the stress-inflammation connection and learn how we can break free from this cycle!

Key Takeaways

Table of Contents

The Stress-Inflammation Connection:
• Chronic stress and inflammation are closely linked, often creating a self-perpetuating cycle.
• This cycle can contribute to various health issues, including cardiovascular diseases, autoimmune disorders, and cognitive decline.
Holistic Approaches to Breaking the Cycle:
• Addressing both stress and inflammation simultaneously is crucial for effective intervention.
• Lifestyle modifications, nutritional strategies, herbal support, and mindbody techniques all play important roles in managing this cycle.
The Role of Herbs:
• Adaptogenic herbs like Ashwagandha and Rhodiola can help the body adapt to stress.
• Antiinflammatory herbs such as Turmeric and Boswellia may help modulate inflammatory responses.
• Proper usage, quality, and individual considerations are important when incorporating herbs into a wellness plan.
Creating a Personalized Wellness Plan:
• Assess individual needs, goals, and health history to create a tailored approach.
• Combine various strategies for a comprehensive plan.
• Consistency, patience, and regular progress tracking are key to longterm success.
The Wise Woman Approach:
• Embraces the cyclical nature of health and wellness.
• Emphasizes selfcare, selfnurturing practices, and connection with nature.
• Values intuitive wisdom, life experience, and the power of natural rhythms in healing.
Importance of Individualization:
• What works best varies from person to person.
• Regular selfreflection and adjustment of strategies are essential for ongoing wellness.
Longterm Perspective:
• Breaking the stressinflammation cycle is a journey, not a quick fix.
• Embracing this process can lead to deeper understanding and more sustainable health outcomes.

Remember, while this information is grounded in both traditional wisdom and modern research, it's always advisable to consult with healthcare professionals when making significant changes to your health regimen, especially if you have preexisting conditions or are taking medications.

The Science Behind Stress and Inflammation

Stress, a ubiquitous aspect of modern life, is the body’s response to any demand or threat. When we encounter a stressor, our body initiates a complex cascade of physiological reactions known as the stress response. This involves the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, leading to the release of stress hormones such as cortisol and adrenaline (Mariotti, 2015).

Inflammation, on the other hand, is the body’s protective mechanism against injury, infection, or other harmful stimuli. It involves the immune system’s response, characterized by increased blood flow, the release of pro-inflammatory cytokines, and the activation of immune cells (Chen et al., 2018). While acute inflammation is beneficial, chronic inflammation can be detrimental to health.

The stress-inflammation cycle is intricate and bidirectional. Chronic stress can trigger and perpetuate inflammation through several mechanisms:

1. HPA axis dysregulation: Prolonged stress can lead to cortisol resistance and impaired negative feedback of the HPA axis, resulting in sustained inflammation (Cohen et al., 2012).

2. Increased pro-inflammatory cytokines: Stress promotes the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) (Liu et al., 2017).

3. Oxidative stress: Chronic stress increases oxidative stress, which can damage cells and tissues, further promoting inflammation (Black & Garbutt, 2002).

4. Gut microbiome alterations: Stress can disrupt the gut-brain axis and alter the microbiome composition, potentially leading to increased intestinal permeability and systemic inflammation (Karl et al., 2018).

The impact of the stress-inflammation cycle on overall health is far-reaching. Chronic inflammation has been linked to numerous health issues, including:

- Cardiovascular diseases
- Autoimmune disorders
- Metabolic syndrome
- Neurodegenerative diseases
- Certain types of cancer

Recent research has also highlighted the role of stress-induced inflammation in accelerating cellular aging through telomere shortening (Olivieri et al., 2018) and epigenetic modifications (Zannas et al., 2019).

Understanding this intricate relationship between stress and inflammation is crucial for developing effective strategies to break the cycle and promote overall wellness. By addressing both stress management and inflammation reduction, we can work towards achieving a more balanced and resilient state of health.

Common Manifestations of the Stress Inflammation Cycle

The interplay between chronic stress and inflammation can manifest in various ways, affecting both physical and mental well-being. Understanding these manifestations is crucial for recognizing and addressing the cycle.

Physical Signs and Indications

Chronic stress and inflammation often present with subtle yet persistent physical symptoms:

Fatigue and low energy levels (Furtado et al., 2020)
Digestive issues, including bloating and irregular bowel movements (Qin et al., 2014)
Frequent infections due to compromised immune function (Cohen et al., 2012)
Skin problems, such as acne or eczema flare-ups (Chen & Lyga, 2014)
Muscle tension and chronic pain (Generaal et al., 2016)
Sleep disturbances and insomnia (Irwin et al., 2016)

Emotional and Mental Manifestations

The stress-inflammation cycle significantly impacts mental health and cognitive function:

Increased anxiety and depression symptoms (Miller & Raison, 2016)
Mood swings and irritability (Slavich & Irwin, 2014)
Difficulty concentrating and memory issues (Shields et al., 2017)
Decreased motivation and feelings of overwhelm (Dantzer et al., 2008)

Long-term Health Implications

Prolonged exposure to the stress-inflammation cycle can contribute to various chronic conditions:

Cardiovascular diseases (Liu et al., 2017)
Autoimmune disorders (Straub & Schradin, 2016)
Metabolic syndrome and type 2 diabetes (Hotamisligil, 2017)
Neurodegenerative diseases, such as Alzheimer’s (Walker et al., 2019)
Accelerated cellular aging and telomere shortening (Olivieri et al., 2018)

Personal Anecdotes and Clinical Observations

As a vitalist clinical herbalist, I’ve observed the profound impact of the stress-inflammation cycle on individuals’ lives. One client, a 45-year-old executive, presented with persistent fatigue, frequent colds, and increasing anxiety. Through a holistic approach addressing both stress management and inflammatory support, we witnessed significant improvements in her energy levels, immune function, and overall well-being within months.

Another case involved a 60-year-old retiree struggling with chronic pain and sleep issues. By focusing on reducing inflammation through dietary changes and herbal support, while simultaneously implementing stress-reduction techniques, we saw a marked decrease in pain levels and improved sleep quality.

These experiences underscore the importance of recognizing the interconnectedness of stress and inflammation in our approach to wellness. By addressing both aspects simultaneously, we can support the body’s innate ability to restore balance and promote long-term health.

Breaking the Cycle: Holistic Approaches

Addressing the stress-inflammation cycle requires a multifaceted approach that targets both stress reduction and inflammatory modulation simultaneously. As a vitalist clinical herbalist, I’ve observed that this holistic strategy often yields more sustainable results than addressing either component in isolation.

Importance of Addressing Both Stress and Inflammation

Research indicates that stress and inflammation are intricately linked, with each capable of exacerbating the other (Liu et al., 2017). By targeting both aspects concurrently, we can potentially break the cycle more effectively and promote overall wellness (Slavich, 2020).

Lifestyle Modifications to Reduce Stress

Implementing stress-reducing practices can significantly impact both mental well-being and inflammatory markers:

Regular physical activity, particularly moderate-intensity exercise (Hamer et al., 2012)
Adequate sleep hygiene and consistent sleep patterns (Irwin et al., 2016)
Time in nature, which has been shown to reduce stress hormones (Hunter et al., 2019)
Social connections and support systems (Uchino et al., 2018)

Nutritional Strategies to Support Balance

Diet plays a crucial role in both stress management and inflammation reduction:

Anti-inflammatory diet rich in fruits, vegetables, and omega-3 fatty acids (Firth et al., 2020)
Mindful eating practices to reduce stress-related overeating (Warren et al., 2017)
Adequate hydration to support overall bodily functions (Pross et al., 2014)
Limiting processed foods, refined sugars, and excessive alcohol consumption (Bonaccio et al., 2018)

Herbal Allies for Stress Management and Inflammatory Support

Certain herbs have demonstrated potential in addressing both stress and inflammation:

Adaptogens like Rhodiola rosea and Ashwagandha for stress resilience (Panossian & Wikman, 2010)
Anti-inflammatory herbs such as Turmeric and Boswellia (Hewlings & Kalman, 2017)
Nervine herbs like Lemon Balm and Passionflower for calming effects (Shakeri et al., 2016)

Mind-Body Techniques for Overall Wellness

Practices that integrate mental and physical well-being can be particularly effective:

Mindfulness meditation, shown to reduce both perceived stress and inflammatory markers (Pascoe et al., 2017)
Yoga and Tai Chi, which combine physical activity with mindfulness (Wang et al., 2014)
Deep breathing exercises to activate the parasympathetic nervous system (Ma et al., 2017)
Progressive muscle relaxation for reducing physical tension (Kwekkeboom & Gretarsdottir, 2006)

By integrating these holistic approaches, individuals can work towards breaking the stress-inflammation cycle and fostering long-term wellness. It’s important to remember that everyone’s journey is unique, and what works best may vary from person to person. As a practitioner, I encourage clients to explore these various strategies and find the combination that resonates best with their individual needs and lifestyle.

The Role of Herbs in Supporting Balance

As a vitalist clinical herbalist, I’ve witnessed the profound impact that carefully selected herbs can have in supporting the body’s natural balance, particularly in the context of the stress-inflammation cycle.

Overview of Adaptogenic Herbs

Adaptogens are a class of herbs that help the body adapt to stress and promote homeostasis. Key adaptogens include:

Ashwagandha (Withania somnifera): Known for its stress-reducing and anti-inflammatory properties (Chandrasekhar et al., 2012).
Rhodiola (Rhodiola rosea): Shown to combat fatigue and enhance mental performance under stress (Anghelescu et al., 2018).
Holy Basil (Ocimum sanctum): Demonstrates potential in modulating both stress and inflammatory responses (Cohen, 2014).

Research suggests that adaptogens work by modulating the hypothalamic-pituitary-adrenal (HPA) axis and supporting cellular energy metabolism (Panossian & Wikman, 2010).

Anti-inflammatory Herbs and Their Properties

Several herbs have demonstrated significant anti-inflammatory properties:

Turmeric (Curcuma longa): Contains curcumin, a potent anti-inflammatory compound (Hewlings & Kalman, 2017).
Ginger (Zingiber officinale): Shown to inhibit inflammatory mediators (Mashhadi et al., 2013).
Boswellia (Boswellia serrata): Contains boswellic acids that have anti-inflammatory effects (Yu et al., 2020).

These herbs work through various mechanisms, including inhibition of pro-inflammatory enzymes and modulation of inflammatory cytokines.

Incorporating Herbs into Daily Routines

Integrating herbs into daily life can be simple and enjoyable:

Herbal teas: A calming cup of chamomile or lemon balm tea can be a soothing ritual.
Culinary herbs: Incorporating turmeric or ginger into cooking adds both flavor and health benefits.
Tinctures or extracts: These concentrated forms can be easily added to water or juice.
Capsules: For those preferring a more standardized approach.

Consistency is key – regular, moderate use often yields better results than sporadic, high doses.

a cup of stomach soothing herbal tea with woman holding cup

Why Herbalists often suggest tea first. . .

Tea is a practical and accessible way to incorporate herbal solutions into daily routines.
It gently extracts beneficial compounds from herbs, making it suitable for long-term use and sensitive individuals.
The body easily absorbs these compounds when drinking tea.
Tea also helps maintain hydration and can be a calming ritual that reduces stress.
Additionally, herbal teas can be customized to individual tastes and health needs.

Precautions and Considerations

While herbs can be powerful allies, it’s important to approach their use mindfully:

Quality matters: Source herbs from reputable suppliers to ensure purity and potency.
Potential interactions: Some herbs may interact with medications or affect certain health conditions. For instance, St. John’s Wort is known to interact with various pharmaceuticals (Asher et al., 2017).
Individual responses vary: What works well for one person may not be as effective for another.
Dosage is crucial: More is not always better. Follow recommended dosages or consult with a qualified herbalist.
Pregnancy and breastfeeding: Extra caution is needed during these times, as some herbs may not be suitable.

As with any wellness approach, it’s advisable to consult with a healthcare provider, especially for those with pre-existing health conditions or taking medications.

By thoughtfully incorporating herbs into a holistic wellness plan, we can harness nature’s wisdom to support our body’s innate balancing mechanisms, potentially breaking the stress-inflammation cycle and fostering overall well-being.

Creating a Personalized Wellness Plan

As a vitalist clinical herbalist with over two decades of experience, I’ve observed that the most effective approaches to breaking the stress-inflammation cycle are those tailored to an individual’s unique needs and circumstances.

lifestyle and wellness – a balancing act

Assessing Individual Needs and Goals

The first step in creating a personalized wellness plan is a comprehensive assessment:

Health history: Understanding past and current health challenges provides crucial context (Fava et al., 2012).
Lifestyle factors: Examining diet, sleep patterns, physical activity, and stress levels offers insights into areas for improvement (Loef & Walach, 2012).
Personal goals: Clarifying what wellness means to the individual ensures the plan aligns with their aspirations (Roscoe, 2009).
Biomarkers: When appropriate, measuring inflammatory markers or stress hormones can provide objective data (Slavich, 2020).

Combining Strategies for a Holistic Approach

An effective wellness plan integrates various elements to address the stress-inflammation cycle comprehensively:

Stress management techniques: Incorporating mindfulness, breathing exercises, or adaptogenic herbs (Pascoe et al., 2017).
Anti-inflammatory nutrition: Emphasizing whole foods and herbs known to modulate inflammation (Firth et al., 2020).
Physical activity: Tailoring exercise recommendations to individual preferences and capabilities (Hamer et al., 2012).
Sleep optimization: Addressing sleep hygiene and incorporating supportive herbs if needed (Irwin et al., 2016).
Social connection: Fostering supportive relationships, which play a crucial role in stress resilience (Uchino et al., 2018).

Importance of Consistency and Patience

Sustainable change often requires time and persistence:

Start small: Beginning with manageable changes increases the likelihood of long-term adherence (Gardner et al., 2012).
Build habits: Consistency in daily practices allows the body to adapt and respond positively (Wood & Rünger, 2016).
Expect fluctuations: Progress is rarely linear; understanding this can help maintain motivation during challenging periods (Schwarzer, 2008).

Tracking Progress and Adjusting as Needed

Regular evaluation and flexibility are key to a successful wellness plan:

Keep a journal: Documenting symptoms, energy levels, and mood can reveal patterns over time (Burton et al., 2007).
Regular check-ins: Scheduling periodic reviews allows for timely adjustments to the plan (Michie et al., 2009).
Celebrate small wins: Acknowledging progress, no matter how small, reinforces positive changes (Amabile & Kramer, 2011).
Be open to adjustments: As circumstances change, the wellness plan should evolve accordingly (Prochaska et al., 2008).

Creating a personalized wellness plan to address the stress-inflammation cycle is an ongoing process of discovery and refinement. By combining scientific insights with individual experiences and preferences, we can craft approaches that not only alleviate symptoms but also foster deep, lasting wellness. Remember, the journey to balance is unique for each individual, and embracing this uniqueness is key to sustainable health.

The Wise Woman Approach to Stress and Inflammation

I’ve come to deeply appreciate the Wise Woman Approach in addressing the stress-inflammation cycle. This holistic perspective integrates traditional wisdom with modern understanding, offering a unique and empowering path to wellness.

Embracing the Cyclical Nature of Health and Wellness

The Wise Woman Approach recognizes that health, like nature, moves in cycles:

Acknowledging fluctuations: Understanding that energy levels, symptoms, and overall well-being naturally ebb and flow can reduce stress about temporary setbacks (Lichtenstein, 2019).
Aligning with natural rhythms: Syncing daily activities with circadian rhythms can optimize bodily functions and reduce stress (Abbott et al., 2018).
Honoring life stages: Recognizing that health needs evolve throughout life stages allows for more compassionate self-care (Northrup, 2010).

Importance of Self-Care and Self-Nurturing Practices

Self-nurturing is central to the Wise Woman tradition:

Nourishing rituals: Engaging in regular self-care practices, such as herbal baths or mindful tea ceremonies, can significantly reduce stress (Leavitt et al., 2018).
Body wisdom: Listening to and honoring the body’s signals promotes a deeper connection with oneself and can help prevent stress-induced inflammation (Pert, 1997).
Pleasure as medicine: Recognizing the healing power of joy and pleasure in reducing stress and inflammation (Kiecolt-Glaser et al., 2002).

Connecting with Nature and Its Rhythms

The Wise Woman Approach emphasizes our inherent connection with nature:

Earthing: Direct contact with the earth, such as walking barefoot, may help reduce inflammation and stress (Chevalier et al., 2012).
Seasonal eating: Consuming local, seasonal foods aligns the body with nature’s cycles and can support overall health (Minich, 2020).
Nature immersion: Regular time spent in natural settings has been shown to reduce stress hormones and inflammatory markers (Li et al., 2011).

Cultivating Resilience and Inner Wisdom

Building resilience is key to long-term stress management and inflammation reduction:

Mindfulness practices: Regular meditation or mindful breathing can enhance stress resilience and reduce inflammatory responses (Creswell et al., 2016).
Intuitive herbalism: Developing a personal relationship with herbs can lead to more intuitive and effective use for stress and inflammation management (Gladstar, 2012).
Embracing elderhood: Recognizing the value of accumulated wisdom and life experience in navigating health challenges (Bolen, 2001).

Wise woman Tasha Tudor — Wise women according to Tolkien (and the wise Tasha Tudor pictured)

The Wise Woman Approach offers a compassionate, nature-aligned perspective on managing the stress-inflammation cycle. By embracing our innate wisdom, honoring natural cycles, and cultivating a deep connection with ourselves and the natural world, we can build resilience and foster true wellness. This approach reminds us that health is not a destination but a journey—one that can be rich with learning, growth, and deep nourishment at every stage of life.

FAQ: The Stress-Inflammation Connection: Breaking Free From the Cycle

Q: What are the signs I’m stuck in a stress-inflammation cycle?
(Keywords: stress symptoms, inflammation signs)
A: Look out for persistent fatigue, frequent illnesses, unexplained aches, anxiety, and trouble sleeping. These could indicate you’re caught in the cycle. Pay attention to your body – if you feel constantly “off” or run down, it might be time to address stress and inflammation.
Q: How can I break the stress-inflammation cycle naturally?
(Keywords: natural stress relief, anti-inflammatory lifestyle)
A: Start with simple steps: practice deep breathing or meditation daily, eat more colorful fruits and veggies, and prioritize sleep. Try gentle exercise like walking or yoga. Herbal allies like ashwagandha for stress and turmeric for inflammation can help too. Remember, consistency is key!
Q: Can certain foods help reduce both stress and inflammation?
(Keywords: anti-inflammatory diet, stress-reducing foods)
A: Absolutely! Focus on colorful berries, leafy greens, fatty fish, and nuts. These foods are rich in antioxidants and omega-3s that fight inflammation. Don’t forget dark chocolate and green tea – they contain compounds that can help lower stress hormones. Aim to “eat the rainbow” daily.
Q: How long does it take to see improvements when addressing the stress-inflammation cycle?
(Keywords: healing timeline, stress recovery)
A: Everyone’s different, but many people start noticing small improvements within 2-4 weeks of consistent changes. You might sleep better or have more energy. Major shifts can take 3-6 months. Be patient and celebrate small wins – they add up to big changes over time!
Q: What role do adaptogens play in managing the stress-inflammation cycle?
(Keywords: adaptogenic herbs, stress management herbs)
A: Adaptogens like rhodiola and ashwagandha help your body resist stress and balance your system. They can boost energy, improve mood, and support your immune system. Start with one adaptogen, take it consistently for a few weeks, and notice how you feel. Always check with a healthcare provider first.

Conclusion

Breaking free from the stress-inflammation cycle is a journey that requires patience, self-compassion, and a holistic approach. By understanding the connection between stress and inflammation and implementing natural strategies to support balance, we can cultivate lasting wellness and vitality. Remember, every small step towards balance is a victory – embrace the process and trust in your body’s innate wisdom to heal and thrive!

Abbott, S. M., Malkani, R. G., & Zee, P. C. (2018). Circadian disruption and human health: A bidirectional relationship. European Journal of Neuroscience, 51(1), 567-583.
Amabile, T., & Kramer, S. (2011). The progress principle: Using small wins to ignite joy, engagement, and creativity at work. Harvard Business Press.
Anghelescu, I. G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: A review. International Journal of Psychiatry in Clinical Practice, 22(4), 242-252.
Asher, G. N., Corbett, A. H., & Hawke, R. L. (2017). Common herbal dietary supplement—drug interactions. American Family Physician, 96(2), 101-107.
Black, P. H., & Garbutt, L. D. (2002). Stress, inflammation and cardiovascular disease. Journal of Psychosomatic Research, 52(1), 1-23.
Bolen, J. S. (2001). Goddesses in older women: Archetypes in women over fifty. HarperOne.
Bonaccio, M., et al. (2018). Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: Results from the Moli-sani study. Blood, 131(14), 1553-1562.
Burton, C., Weller, D., & Sharpe, M. (2007). Are electronic diaries useful for symptoms research? A systematic review. Journal of Psychosomatic Research, 62(5), 553-561.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine, 34(3), 255-262.
Chen, Y., & Lyga, J. (2014). Brain-skin connection: Stress, inflammation and skin aging. Inflammation & Allergy-Drug Targets, 13(3), 177-190.
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., … & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204-7218.
Chevalier, G., Sinatra, S. T., Oschman, J. L., Sokal, K., & Sokal, P. (2012). Earthing: Health implications of reconnecting the human body to the Earth’s surface electrons. Journal of Environmental and Public Health, 2012, 291541.
Cohen, M. M. (2014). Tulsi – Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251-259.
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proceedings of the National Academy of Sciences, 109(16), 5995-5999.
Creswell, J. D., Taren, A. A., Lindsay, E. K., Greco, C. M., Gianaros, P. J., Fairgrieve, A., Marsland, A. L., Brown, K. W., Way, B. M., Rosen, R. K., & Ferris, J. L. (2016). Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: A randomized controlled trial. Biological Psychiatry, 80(1), 53-61.
Dantzer, R., et al. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9(1), 46-56.
Fava, G. A., et al. (2012). The clinical value of well-being therapy. In G. A. Fava & C. Ruini (Eds.), Increasing psychological well-being in clinical and educational settings (pp. 13-37). Springer.
Firth, J., et al. (2020). Food and mood: How do diet and nutrition affect mental wellbeing? BMJ, 369, m2382.
Furtado, M., et al. (2020). The prevalence and burden of psychiatric and chronic pain comorbidities in acute coronary syndrome patients: A systematic review. Systematic Reviews, 9(1), 1-13.
Gardner, B., Lally, P., & Wardle, J. (2012). Making health habitual: The psychology of ‘habit-formation’ and general practice. British Journal of General Practice, 62(605), 664-666.
Generaal, E., et al. (2016). Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: A 6-year cohort study. Annals of the Rheumatic Diseases, 75(5), 847-854.
Gladstar, R. (2012). Rosemary Gladstar’s medicinal herbs: A beginner’s guide. Storey Publishing.
Hamer, M., et al. (2012). Physical activity and inflammatory markers over 10 years: Follow-up in men and women from the Whitehall II cohort study. Circulation, 126(8), 928-933.
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A review of its effects on human health. Foods, 6(10), 92.
Hotamisligil, G. S. (2017). Inflammation, metaflammation and immunometabolic disorders. Nature, 542(7640), 177-185.
Hunter, M. R., et al. (2019). Urban nature experiences reduce stress in the context of daily life based on salivary biomarkers. Frontiers in Psychology, 10, 722.
Irwin, M. R., et al. (2016). Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biological Psychiatry, 80(1), 40-52.
Karl, J. P., Hatch, A. M., Arcidiacono, S. M., Pearce, S. C., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018). Effects of psychological, environmental and physical stressors on the gut microbiota. Frontiers in Microbiology, 9, 2013.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002). Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology. Annual Review of Psychology, 53, 83-107.
Kwekkeboom, K. L., & Gretarsdottir, E. (2006). Systematic review of relaxation interventions for pain. Journal of Nursing Scholarship, 38(3), 269-277.
Leavitt, K., Zhu, L., & Aquino, K. (2018). Good without knowing it: Subtle contextual cues can activate moral identity and reshape moral intuition. Journal of Business Ethics, 154(4), 1063-1077.
Li, Q., Otsuka, T., Kobayashi, M., Wakayama, Y., Inagaki, H., Katsumata, M., Hirata, Y., Li, Y., Hirata, K., Shimizu, T., Suzuki, H., Kawada, T., & Kagawa, T. (2011). Acute effects of walking in forest environments on cardiovascular and metabolic parameters. European Journal of Applied Physiology, 111(11), 2845-2853.
Lichtenstein, D. (2019). Cycles of Wisdom: Walking with the rhythms of nature. Balboa Press.
Liu, Y. Z., Wang, Y. X., & Jiang, C. L. (2017). Inflammation: The common pathway of stress-related diseases. Frontiers in Human Neuroscience, 11, 316.
Liu, Y. Z., et al. (2017). Inflammation: The common pathway of stress-related diseases. Frontiers in Human Neuroscience, 11, 316.
Loef, M., & Walach, H. (2012). The combined effects of healthy lifestyle behaviors on all cause mortality: A systematic review and meta-analysis. Preventive Medicine, 55(3), 163-170.
Ma, X., et al. (2017). The effect of diaphragmatic breathing on attention, negative affect and stress in healthy adults. Frontiers in Psychology, 8, 874.
Mariotti, A. (2015). The effects of chronic stress on health: New insights into the molecular mechanisms of brain-body communication. Future Science OA, 1(3), FSO23.
Mashhadi, N. S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L., & Mofid, M. R. (2013). Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. International Journal of Preventive Medicine, 4(Suppl 1), S36-S42.
Michie, S., et al. (2009). Effective techniques in healthy eating and physical activity interventions: A meta-regression. Health Psychology, 28(6), 690-701.
Miller, A. H., & Raison, C. L. (2016). The role of inflammation in depression: From evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16(1), 22-34.
Minich, D. M. (2020). A review of the science of colorful, plant-based food and practical strategies for “eating the rainbow”. Journal of Nutrition and Metabolism, 2020, 2125070.
Northrup, C. (2010). Women’s bodies, women’s wisdom: Creating physical and emotional health and healing. Bantam.
Olivieri, F., Albertini, M. C., Orciani, M., Ceka, A., Cricca, M., Procopio, A. D., & Bonafè, M. (2015). DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging. Oncotarget, 6(34), 35509-35521.
Olivieri, F., et al. (2018). Cellular senescence in cardiovascular diseases: Potential age-related mechanisms and implications for treatment. Current Pharmaceutical Design, 24(3), 274-280.
Panossian, A., & Wikman, G. (2010). Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals, 3(1), 188-224.
Pascoe, M. C., et al. (2017). Mindfulness mediates the physiological markers of stress: Systematic review and meta-analysis. Journal of Psychiatric Research, 95, 156-178.
Pert, C. B. (1997). Molecules of emotion: Why you feel the way you feel. Scribner.
Prochaska, J. O., et al. (2008). The transtheoretical model and stages of change. In K. Glanz, B. K. Rimer, & K. Viswanath (Eds.), Health behavior and health education: Theory, research, and practice (4th ed., pp. 97-121). Jossey-Bass.
Pross, N., et al. (2014). Effects of changes in water intake on mood of high and low drinkers. PloS One, 9(4), e94754.
Qin, H. Y., et al. (2014). Impact of psychological stress on irritable bowel syndrome. World Journal of Gastroenterology, 20(39), 14126-14131.
Roscoe, L. J. (2009). Wellness: A review of theory and measurement for counselors. Journal of Counseling & Development, 87(2), 216-226.
Schwarzer, R. (2008). Modeling health behavior change: How to predict and modify the adoption and maintenance of health behaviors. Applied Psychology, 57(1), 1-29.
Shakeri, A., et al. (2016). Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, 188, 204-228.
Shields, G. S., et al. (2017). The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol. Neuroscience & Biobehavioral Reviews, 68, 651-668.
Slavich, G. M. (2020). Social safety theory: A biologically based evolutionary perspective on life stress, health, and behavior. Annual Review of Clinical Psychology, 16, 265-295.
Slavich, G. M., & Irwin, M. R. (2014). From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychological Bulletin, 140(3), 774-815.
Straub, R. H., & Schradin, C. (2016). Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evolution, Medicine, and Public Health, 2016(1), 37-51.
Uchino, B. N., et al. (2018). Social support, social integration, and inflammatory cytokines: A meta-analysis. Health Psychology, 37(5), 462-471.
Walker, K. A., et al. (2019). Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study. Neurology, 92(11), e1256-e1267.
Wang, C., et al. (2014). Effect of tai chi on cognitive performance in older adults: Systematic review and meta analysis. Journal of the American Geriatrics Society, 62(1), 25-39.
Warren, J. M., et al. (2017). A structured literature review on the role of mindfulness, mindful eating and intuitive eating in changing eating behaviours: Effectiveness and associated potential mechanisms. Nutrition Research Reviews, 30(2), 272-283.
Wood, W., & Rünger, D. (2016). Psychology of habit. Annual Review of Psychology, 67, 289-314.
Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: A systematic review and meta-analysis. BMC
Complementary Medicine and Therapies, 20(1), 225.
Zannas, A. S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J. C., … & Binder, E. B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences, 116(23), 11370-11379.

The Stress-Inflammation Cycle